Delivering High-Quality Instruction Online in Response to COVID-19 is a faculty-focused playbook intended to improve course design, teaching, and learning in online environments. With special attention to the needs of instructors teaching online for the first time, the guide offers strategies for getting started and improving over time. The playbook provides a path for continuous improvement of instruction along a quality-oriented continuum. Design guides immediate and basic needs for moving a course online. It is useful for translation of face-to-face or blended courses for fully-online delivery. Enhance provides options to strengthen the student learning experience. It is useful for improving face-to-face course elements that do not translate easily to online modalities. Optimize offers ideas and resources for online teaching that aligns with high-quality, evidence-based instructional practices. It is useful for continuous improvement of the online learning experience and student outcomes. In addition, Delivering High-Quality Instruction Online in Response to COVID-19 addresses online teaching and learning in both emergency and non-emergency contexts with special attention to course design, course construction, course management, course evaluation, and strategies for continuous improvement.